We study principles of neural circuit function and malfunction in neurological disease states. Tools used range from in vivo 2-photon imaging, optogenetics, classical electrophysiology, to functional magnetic resonance imaging (fMRI). Active projects...
The Precision Neuroscience & Neuromodulation (PNN) program at MGH, directed by Dr. Emiliano Santarnecchi, leverages the combination of multimodal neuroimaging techniques (e.g., fMRI, DTI and PET), electrophysiology, cognitive neuroscience, computational...
The Megason Lab uses imaging-based systems biology to elucidate the systems level principles of animal development. We are particularly interested in long standing problems in embryology whose understanding has defied molecular reduction namely...
The brain, which represents 2% of the body mass but consumes 20% of the body energy at rest, is therefore highly dependent on oxygen and nutrients supply from the blood stream. Key to the functional interdependence between neural and vascular systems is...
Dr. Siddiqi is a neuropsychiatrist whose research is focused on causal mapping of human brain function and dysfunction. Using techniques such as functional connectivity MRI, his lab maps brain circuits to link brain lesions and brain stimulation sites...
The broad aim of the research in my lab is to characterize representational spaces of the mind and how they are mapped onto the surface of the brain. We focus primarily on high-level visual representation: How do we organize our knowledge of objects...
The overarching aim of our research is to advance our understanding of the neurobiology of depression and related disorders (e.g., bipolar disorders, anxiety). The ultimate goal of this work is to identify novel targets for prevention and treatment. We...