I study the effects of cannabis use on addiction and other health outcomes, as well at the intersection between cannabis and mental health. My research combines multi-modal neuroimaging with clinical trials and behavioral and cognitive testing to understand the biological, psychological, and clinical aspects of addiction. Using multimodal imaging, my goal is to conduct research that can inform decision-making among the public, patients, and clinicians regarding evidence-based decisions to use or not use cannabis for recreational or medical purposes. Specifically, I am studying (1) cannabis use and brain/cognitive changes among adolescents and vulnerable populations such as those with psychiatric illnesses, and (2) potential medicinal properties of components of the cannabis plant and specifically of cannabidiol (CBD), a much-needed area of research considering the interest among the public surrounding CBD. I have received two NIDA Career Development Awards; a K01 to develop novel neuroimaging paradigms to investigate the effect of social influence and drug use on brain function, and a K02 to learn big data techniques and complete a series of analyses investigating impulsivity in adolescent drug use using the Adolescent Brain Cognitive Development (ABCD) dataset. I am currently running several clinical trials; (1) investigating the role of medical cannabis on escalation to addiction, neurocognitive effects, and functional brain changes, (2) investigating the role of cannabidiol on neuroinflammation using PET scanning in patients with low back pain, and (3) investigating whether cannabis is effective for patients with chronic pain on chronic opioid therapy to taper their opioid dose and manage pain.