Christiane Wrann

Christiane Wrann

Assistant Professor of Medicine
Christiane Wrann
Preserving cognitive function is a major challenge in an increasingly aging population. Alzheimer's disease alone affects an estimated 5.5 million Americans today. Unfortunately, effective treatment options are still very limited. Interestingly, exercise is known to have positive effects on brain health. Exercise improves cognitive functions, stimulates adult hippocampal neurogenesis, and reduces neuroinflammation. Our research focuses on uncovering the molecular mechanisms linking exercise to neuroprotection in aging and neurodegeneration. The goal is to identify novel therapeutic targets and biomarkers for brain health in aging and neurodegenerative diseases, such as Alzheimer's disease. A special focus is secreted factors, which are desirable candidates for biomarkers or therapies. To accomplish our goals, we have established an interdisciplinary research program that integrates preclinical mouse models and human translational studies. In addition to traditional molecular and genetic approaches, we employ cutting-edge technologies, such as single-cell RNA-sequencing, high-resolution mass spectrometry, and advanced molecular imaging.

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Massachusetts General Hospital East
149 13th Street, Rm. 4.018
Charlestown, MA 02129
p: 617-643-3443

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