The research interests of the Schwarz lab are centered on the use of genetics to probe the cell biology of the nervous system. We use Drosophila, mouse, and rat neurons to investigate such topics as 1) the manner in which membrane organelles are moved...
Thesis advisor: David Ginty
Rotation lab(s): Chenghua Gu, Clifford Woolf, Isaac Chiu
For me, home is: Kazakhstan
Undergraduate degree(s): BS Biological Sciences
Research experience before PiN: I've been mostly involved in Cell/Molecular Biology research in...
Thesis advisor: Bernardo Sabatini
Rotation labs: Bob Datta, Bernardo Sabatini, Dragana Rogulja, Carlos Ponce
For me, home is: Tehran, Iran
Prior degree(s): B.S. in Mathematics (Tehran University), M.S. in Cognitive Science - Cognitive Neuroscience track...
Glutamate homeostasis
Neurotransmitter transporters, like ion channels, play essential roles at synapses in the central nervous system as the major regulators of glutamate homeostasis. Glutamate homeostasis has been found to be important in the...
The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...
The brain allows animals to successfully interact with a natural world that is rich with opportunity and rife with danger. These interactions are mediated by sensation and movement, which are used by animals to learn about their environment and to make...
The goal of our lab is to advance our understanding of the molecular, cellular, and systems neuroscience mechanisms which underlie neuropsychiatric disease. I have focused on the neurobiology of fear in mouse models and the pathophysiology of fear...
The molecular mechanisms underlying neurodegeneration in human disorders like Alzheimer's disease and Parkinson's disease remain mysterious, in part because genetic analysis in patients and vertebrate models is laborious. Disease models in simpler...
We study principles of neural circuit function and malfunction in neurological disease states. Tools used range from in vivo 2-photon imaging, optogenetics, classical electrophysiology, to functional magnetic resonance imaging (fMRI). Active projects...