We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...
Voluntary limb movements are fundamental to human life, as evidenced by the severe functional limitations that beset those with life-long paralysis after spinal cord injury (SCI). Humans routinely coordinate a broad range of limb movements to accomplish...
The Precision Neuroscience & Neuromodulation (PNN) program at MGH, directed by Dr. Emiliano Santarnecchi, leverages the combination of multimodal neuroimaging techniques (e.g., fMRI, DTI and PET), electrophysiology, cognitive neuroscience, computational...
Every decision and behavior is haunted by uncertainty, introduced by the noisy and ambiguous nature of the world that surrounds us. Despite this, we make such decisions with seeming ease. Our goal is to understand the fundamental computations and their...
In our lab in the Department of Neurobiology at Harvard Medical School, we worked for many years with non-human primates (NHPs) on a wide variety of questions, including neuronal mechanisms of attention, inference and flexible coding in parietal cortex...
Certain basic cognitive processes are central to navigating the world around us. Attention, for example is important for almost all of our conscious actions, yet there's so much we still don't know about the cell types and circuits that support it...
The brain creates memories and expectations through experience interacting with the world around it and decides what it will do with its future given what it already knows and what it predicts will happen. The person in whom the brain resides is aware of...