Neuronal Tissue and Cell Culture

We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...

Our research seeks to understand how protein synthesis at the synapse is used to facilitate experience-dependent changes in brain function. Advances in technology have led to an increasingly complex picture of the RNA landscape of the neuron. Specific...

My lab is developing new approaches to imaging brain cells and tissues using custom molecular probes that provide color in electron microscopy. We also have another research direction where we use time-resolved cryo-vitrification to study the...

A long-term goal of my laboratory is to address mechanisms of cellular fatty acid metabolism and their implication in neuronal functions. Fatty acids are essential for life but are toxic in their free form, as they can readily transform into highly...

Our lab is focused on the deep-molecular characterization of a clinically well-defined cohort of patients with neurodegenerative diseases anchored in genomic data. We use a multi-disciplinary approach applying high-throughput technologies to generate a...

We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...

The major research interest of our laboratory is the genetic control of the development and behavior of the nematode Caenorhabditis elegans, with the goal of understanding fundamental aspects of biology and revealing insights into human disease.  The...

The Enteric Nervous System, which is the largest subdivision of the peripheral nervous system, regulates key gastrointestinal and systemic functions of digestion, metabolism, immunity, and maintenance of intestinal microbiota. Using various lineage...

Preserving cognitive function is a major challenge in an increasingly aging population. Alzheimer's disease alone affects an estimated 5.5 million Americans today. Unfortunately, effective treatment options are still very limited. Interestingly, exercise...

The Tang lab seeks to understand the molecular and cellular basis of human brain disorders in order to ultimately develop precision medicine therapeutics. We leverage cutting-edge technologies including single-cell RNA sequencing, CRISPR gene editing...