Human-machine integration seeks to harmonize advanced engineering with the human body’s complex biological systems, a task that remains challenging due to the limitations of current technology and the separation between disciplines like engineering...
We study principles of neural circuit function and malfunction in neurological disease states. Tools used range from in vivo 2-photon imaging, optogenetics, classical electrophysiology, to functional magnetic resonance imaging (fMRI). Active projects...
The Enteric Nervous System, which is the largest subdivision of the peripheral nervous system, regulates key gastrointestinal and systemic functions of digestion, metabolism, immunity, and maintenance of intestinal microbiota. Using various lineage...
Dr. Cash's research focuses on understanding the mechanisms underlying both normal and pathological cortical activity and developing novel neuroprosthetic (brain computer interfaces) approaches for treating a wide variety of neurological problems. This...
Our research focuses on understanding the neural circuitry that controls arousal and sleep, and how the function of this circuitry is disrupted in narcolepsy and other sleep disorders.
A major line of investigation is to determine how this circuitry is...
Our lab's projects lie at the intersection of genetics, neurobiology, and bioinformatics, which we apply to understand (and treat) rare pediatric neurologic diseases.
Autism genetics and neurobiology: We apply whole exome and whole genome sequencing to...
Our lab aims to understand the in vivo functions of certain genes identified in neurodegenerative and developmental disorders of the human brain such as schizophrenia, Alzheimer's disease, lissencephaly, autism and mental retardation. We use a variety...
My lab explores new strategies for the treatment of Parkinson's disease (PD) and related synucleinopathies such as Dementia with Lewy bodies (DLB), Multi-System Atrophy (MSA) and, to some extent, also Alzheimer's disease (AD). These diseases are...