Dr. Cash's research focuses on understanding the mechanisms underlying both normal and pathological cortical activity and developing novel neuroprosthetic (brain computer interfaces) approaches for treating a wide variety of neurological problems. This work has melded issues spanning basic neuroscientific questions of the physiology that underlie normal oscillatory activity, sleep and cognition, to issues surrounding how the brain transitions from one state to another including from normal activity to seizure activity and how seizures can be localized and treated. The majority of work in the lab involves recordings with both clinical electrodes and research electrodes in patients undergoing surgery for epilepsy or brain tumors. The work utilizes signal processing, advanced recording techniques as well as machine learning approaches in order to discover fundamental mechanisms underlying neural processing in the human brain and how we can interact with nervous system to alleviate and cure major neuropsychiatric diseases. Dr. Cash's research focuses on understanding the mechanisms underlying both normal and pathological cortical activity and developing novel neuroprosthetic (brain computer interfaces) approaches for treating a wide variety of neurological problems. This work has melded issues spanning basic neuroscientific questions of the physiology that underlie normal oscillatory activity, sleep and cognition, to issues surrounding how the brain transitions from one state to another including from normal activity to seizure activity and how seizures can be localized and treated. The majority of work in the lab involves recordings with both clinical electrodes and research electrodes in patients undergoing surgery for epilepsy or brain tumors. The work utilizes signal processing, advanced recording techniques as well as machine learning approaches in order to discover fundamental mechanisms underlying neural processing in the human brain and how we can interact with nervous system to alleviate and cure major neuropsychiatric diseases.