Every cell in the body needs fuel to function properly and when energy systems fail, disease follows. The United States is currently facing a metabolic health crisis, with more than one-third of adults affected by obesity or diabetes. These metabolic...
The Fanning lab is focused on the role of the metablome in neurodegenerative diseases including Parkinson's disease (PD), Lewy body Dementia (LBD), and other synucleinopathies. Our research is motivated by the huge unmet medical need for mechanism-based...
Our lab studies how sensory cues become linked to adaptive or maladaptive responses through learning. Adaptive responses are necessary to develop, survive and thrive; maladaptive responses contribute to disorders across the lifespan. We study this...
We are broadly interested in molecular programs that shape cognition and behavior. Our current work centers on circulating factors (i.e. hormones)— produced by peripheral organs, influenced by environment and somatic state, and readily measured in human...
The human brain is a mosaic structure with significant genetic diversity arising from post-zygotic (i.e., somatic) genetic variation. The overarching mission of our lab is to examine how this somatic variation contributes to both typical and pathological...
Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...
The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...
The Cox lab is investigating the role of the gut microbiota in neurologic diseases, including Alzheimer's disease, Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. The gut microbiota is composed of trillions of bacteria, fungi...
The brain-CSF interface: Neural stem cells and disease
Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified. Neural precursors divide...