Andreas is interested in connectivity and causality in the brain and focuses on how deep brain stimulation impacts distributed brain networks. He aims to find out how these brain network modulations map onto changes in clinical symptoms and behavior. 

He has published work on how neuromodulation impacts the human connectome in brain disorders such as Parkinson’s Disease, Dystonia, Depression, Obsessive Compulsive Disorder and Alzheimer’s Disease. His laboratory, the network stimulation laboratory (www.netstim.org) develops the open-source Lead-DBS toolbox (www.lead-dbs.org) which has been created to facilitate these types of analyses and is used in laboratories, world-wide. Regularly, the lab uses normative connectomes derived from functional magnetic resonance imaging (rs-fMRI) or diffusion-weighted imaging based tractography (dMRI) to investigate symptom-specific networks in the human brain. 

Key achievements include delineation and replication of specific networks associated with optimal treatment outcomes in obsessive compulsive disorder and Alzheimer’s Disease.

Andreas serves as the director for deep brain stimulation research within the center for brain circuit therapeutics at Brigham and Women's Hospital in Boston and director for connectomic neuromodulation at the department of neurosurgery at Massachusetts General Hospital.