Boston Children's Hospital

The brain-CSF interface: Neural stem cells and disease

Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified. Neural precursors divide...

We seek to understand the mechanisms by which heterogenous cell types orchestrate synchronous network patterns for brain computations as fundamental as memory, which may be key to understanding the origins of pathological hypersynchrony in epilepsy...

Our research seeks to understand how protein synthesis at the synapse is used to facilitate experience-dependent changes in brain function. Advances in technology have led to an increasingly complex picture of the RNA landscape of the neuron. Specific...

We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...

The goal of our laboratory is to understand the mechanisms that underlie synaptic plasticity in the developing and mature mammalian central nervous system. We use a combination of tools, including electrophysiological, in vitro and in vivo optical...

Certain basic cognitive processes are central to navigating the world around us. Attention, for example is important for almost all of our conscious actions, yet there's so much we still don't know about the cell types and circuits that support it...

The Tang lab seeks to understand the molecular and cellular basis of human brain disorders in order to ultimately develop precision medicine therapeutics. We leverage cutting-edge technologies including single-cell RNA sequencing, CRISPR gene editing...

The long-term interest of my research is to bridge molecular, cellular, and system approaches to understand the neuronal modulation and circuitry involved in the pathogenesis of neurological and metabolic diseases. Specifically, we are currently...

The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been...

Restoring lost function after spinal cord injury or other types of CNS injuries is a major challenge of contemporary neuroscience. A key culprit of functional deficits is the disruption and/or dysfunction of axonal connections connecting different parts...