Our research focuses on understanding the neural circuitry that controls arousal and sleep, and how the function of this circuitry is disrupted in narcolepsy and other sleep disorders.
A major line of investigation is to determine how this circuitry is...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
The brain-CSF interface: Neural stem cells and disease
Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified. Neural precursors divide...
Human-machine integration seeks to harmonize advanced engineering with the human body’s complex biological systems, a task that remains challenging due to the limitations of current technology and the separation between disciplines like engineering...
Immune cell modulation is an attractive strategy for the treatment of inflammatory conditions. Inflammation is critical to protecting us from dangers within (e.g. cancer) and without (e.g. microbes). But inflammation also drives much human pathology and...