The Koehler Lab focuses on understanding the development and regeneration of sensory organs. Our primary goal is to elucidate how cells from various layers of the developing embryo converge to form a functioning sense organ. We believe such basic...
We are working to understand (i) how the human genome varies from person to person, and (ii) how inherited genome variation affects the biology of neurons and microglia on its way to affecting brain phenotypes such as risk of bipolar disorder, autism and...
Our lab fuses electrophysiology and stem cell biology in order to explore how abnormal physiology contributes to diseases of the motor and sensory nervous systems. We use primary mouse motor neurons as well as motor neurons derived from human induced...
Our laboratory is directed toward both 1) understanding molecular controls and mechanisms over neuron sub-type development, diversity, axon guidance-circuit formation, and degeneration-disease in the cerebral cortex (e.g. corticospinal motor neurons -...
The goal of our laboratory is to prevent the causes of brain degeneration and loss of neuronal function. In addition, we aim to repair brain function by restoration of new neurons and glia in the brain. We have three major lines of research:
(1) Lipid...
We are interested in the fundamental mechanisms of neurodegenerative disorders like Alzheimer’s disease. Over the past century-plus, research has revealed specific proteins that misfold and are deposited in neurodegeneration, and recent discoveries have...
Our research focuses on identifying how cell biological processes are disrupted in Parkinson's disease and aging, with the overarching goal of our work to identify novel biomarkers and neuroprotective strategies for Parkinson's disease, as well as other...