Embryological

Our lab studies the molecular and cellular basis of novel organismic physiology and behavior. We emphasize curiosity-driven science and exploration, using comparative approaches featuring a range of unusual and specialized organisms that are uniquely...

The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...

The brain-CSF interface: Neural stem cells and disease

Defined numbers of neural precursor cells are remarkably synchronized in their task to form the brain, yet no central command coordinating this process has been identified. Neural precursors divide...

The cortex develops hand-in-glove with its cerebrospinal fluid (CSF)-filled ventricles whose walls harbor neural stem cells (NSCs) destined to become  neurons and glia. Within each ventricle, the choroid plexus (ChP), comprising the blood-CSF immune...

We are a collaborative group of genome editing scientists at the Translational Neuroscience Center of Boston Children’s Hospital and Harvard Medical School department of Neurology. We strive to develop gene-based therapeutics for genetic neurological...

The major research interest of our laboratory is the genetic control of the development and behavior of the nematode Caenorhabditis elegans, with the goal of understanding fundamental aspects of biology and revealing insights into human disease.  The...

The long-term interest of my research is to bridge molecular, cellular, and system approaches to understand the neuronal modulation and circuitry involved in the pathogenesis of neurological and metabolic diseases. Specifically, we are currently...

The human brain is a highly organized structure containing myriad axon tracts that follow precise pathways and make predictable connections, yet only a handful of human disorders clearly resulting from errors in axon growth and guidance have been...

The lab studies diverse topics ranging from the control of neurotransmitter release to the behavioral roles of the cerebellum. Synaptic plasticity has been a long-standing interest of the lab. In recent years we have focused on the molecular control of...

My research program has a translational mission centered around the genetics of epilepsy. We recognize that epilepsy is a common condition with many causes and that people with epilepsy experience morbidity from seizures, neurodevelopmental and...