Dr. Webb's Treatment and Etiology of Depression in Youth (TEDY) Laboratory at McLean Hospital uses a multimodal approach (EEG, fMRI, ecological momentary assessment, and laboratory-based experiments) to investigate the etiology and pathophysiology of depression in adolescents, as well as predictors and mechanisms of change in psychotherapeutic and pharmacological treatments for depression. Relevant to the pursuit of personalized medicine in psychiatry, Dr. Webb's more recent research leverages machine learning to identify pretreatment predictors of symptom improvement in psychotherapeutic and pharmacological treatments for depression. Greater knowledge of variables predicting better or worse treatment response prior to the start of treatment may have important clinical implications regarding which interventions are best suited for whom, thus informing treatment selection. To date, we have strikingly little empirical data to usefully guide the selection of treatments for depressed youth.