Dana Farber Cancer Institute

The Gu Lab focuses on elucidating how cells regulate proteasomal degradation independently of ubiquitination. We discovered a non-canonical proteolysis mechanism, the midnolin-proteasome pathway, that bypasses ubiquitination to selectively degrade...

My research focuses on pediatric brain tumors, particularly high-grade gliomas and  other malignant brain tumors that are in greatest need of therapeutic improvements. I am especially interested in how the specific developmental and cellular contexts in...

Schedule
On Campus Monday - Thursday
Remote on Friday

Research in the Segal Lab is at the interface of neurobiology and cancer biology. We address the interactions between the nervous system and cancers, including the contributions of the nervous system to...