# Curriculum ## expand\_more ## Overview ### G1 Year expand\_more In their first year, PiN students complete at least two part-time [lab rotations](/training/curriculum/rotations) and two required core courses: Quantitative Methods for Biologists (NEUROBIO 306qc), an intensive two-week boot camp in August that introduces students to statistics using Python, and the Discipline of Neuroscience (NEUROBIO 215), PiN's year-long flagship course designed to give students the broad, cross-disciplinary conceptual fluency required of neuroscientists. In consultation with their [SAC advisor](/training/advising-mentorship), students may also choose to complete additional elective courses during their first year. Students are expected to join a lab by July 1, at the end of their first year. ### G2 Year expand\_more [**Preliminary Qualifying Examination (PQE)**](/training/curriculum/pqe) Students are required to take their PQE by March 31 of their second year and should have completed (or have in progress) 4 credits of elective coursework at the time of the exam. G2 students meet with their [SAC advisor](/training/advising-mentorship) in September to discuss preparing for the PQE. The examination comprises a written proposal and an oral presentation and examination. Students are given substantial guidance in preparation for the PQE. The Discipline of Neuroscience first-year course includes a component that trains students in proposal writing. Additionally, students are given many opportunities to practice giving talks before their PQE. [**Dissertation Advisory Committee (DAC)**](/training/advising-mentorship) After passing their PQE, students form a Dissertation Advisory Committee (DAC) in consultation with their thesis advisor. It is not uncommon for students to ask their PQE committee members to continue as DAC members. Students and their thesis advisors are required to meet formally with the DAC at least once every 9 months through the G5 year and every 6 months thereafter to discuss research progress. The DAC advises on project scope and timeline and any issues that may arise. The DAC also advises on career development. ### G3 Year & Above expand\_more Beginning their G3 year, students are required to meet with their [Dissertation Advisory Committee](/training/advising-mentorship) (DAC) at least once every 9 months until the end of their G5 year and every 6 months thereafter to review their research progress and discuss any issues that may arise. The DAC also provides valuable advising on career development. Students are also required to meet with their [SAC advisor](/training/advising-mentorship) every summer until they defend their thesis. Prior to this meeting, students are asked to complete an Individual Development Plan (IDP) designed to help guide discussions about progress to degree and career options (and to collect the data routinely needed to renew training grants). Students are encouraged to help set the agenda for these meetings and might, for example, want to discuss issues relating to their DAC, their advisor, their ideas for postdoctoral research, or alternative post-graduation options. ### MD-PhD expand\_more PiN MD-PhD students are first admitted to the [Harvard/MIT MD-PhD](https://www.hms.harvard.edu/md_phd/) program, where they have the option of applying to two educational tracks through Harvard Medical School: the [Pathways](https://meded.hms.harvard.edu/pathways) track and the [Health Sciences & Technology (HST)](https://meded.hms.harvard.edu/health-sciences-technology) track. Admitted MD-PhD students begin their medical training and apply to PiN during their second medical school (M2) year. MD-PhD students typically complete their lab rotations during their M2 year and declare a thesis lab when they matriculate as PiN students. **Course requirements** In addition to the required PiN core courses (G1: NB 215, Discipline of Neuroscience | G2: MED-SCI 300qc, Conduct of Science), MD-PhD students are required to complete 4 credits of elective coursework (rather than 8 credits), including 2 credits of quantitative coursework, after matriculating as PiN students. MD-PhD students are exempt from the MATLAB/Python bootcamp requirement; if they choose to complete the bootcamp, they are still required to complete an additional 4 credits of elective coursework. PiN strongly encourages MD-PhD students in the Pathways curriculum to take the quarter course NB315qc: Human Neuroanatomy and Neuropathology as one of their electives. ## Course Requirements ### Core Courses expand\_more PiN students are required to take NEUROBIO 306qc (Python Bootcamp in August), 215AB, and 327R in their first year. Students with a strong quantitative background may "test out" of NEUROBIO 306qc with instructor permission. In the fall of their G2 and G6 years, PiN students are required to take the NIH-mandated Conduct of Science course, MED-SCI 300qc/302qc. ##### [NEUROBIO 306qc](https://courses.my.harvard.edu/psp/courses/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22:true,%22SaveRecent%22:true,%22Facets%22:%5B%5D,%22PageNumber%22:1,%22SortOrder%22:%5B%22SCORE%22%5D,%22TopN%22:%22%22,%22PageSize%22:%22%22,%22SearchText%22:%22NEUROBIO%20323qc%22%7D). Quantitative Methods for Biologists (Python) Two weeks in mid-August (August 11-22, 2025) The goal of this summer "boot camp" is to introduce you to programming in the Python environment and to show you the power this provides for analyzing data and for gaining intuition about the behavior of complex systems through the use of numerical simulations. Some of you, upon encountering in the previous sentence words like "programming" and "numerical simulations," will feel the cold hand of fear grip your stomach, because you have never done any programming and, in fact, have tried to avoid math as much as possible. If so, YOU ARE PRECISELY THE PERSON WE HAD IN MIND as we were planning the course. We are aiming to help you break through this barrier of darkness and fear into the radiant sunshine of quantitative enlightenment. The true beauty of Python, as we will personally demonstrate, is that it allows people who are not mathematically adept (e.g., some of the instructors of this course) to use powerful numerical methods and visualization tools to gain an understanding of concepts that are very difficult to grasp analytically. ##### [NEUROBIO 215](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22:true,%22SaveRecent%22:true,%22Facets%22:%5B%5D,%22PageNumber%22:1,%22SortOrder%22:%5B%22SCORE%22%5D,%22TopN%22:%22%22,%22PageSize%22:%22%22,%22SearchText%22:%22neurobio%20215%22%7D). Discipline of Neuroscience Course Directors: Mark Andermann, John Assad Fall & Spring, Tue & Thu, 9am - 12pm This course will endow students with the broad conceptual fluency in the discipline of neuroscience required to relate genes to circuit function, metabolism to neurological disease, and cell biology to neural computations. Through a combination of lectures and in-class activities, students will learn to design, quantitatively analyze, and interpret experiments that address a variety of questions spanning molecular to systems neuroscience. During the first semester, students will think critically about the fundamental units of the nervous system within the context of cellular function, electrical conduction, and chemical signaling. The second half of the course builds upon this foundation to focus on broadly defined “networks of neural function” as related to coordinated neural activity, the concerted execution of genetic programs, and anatomically defined structural networks. The course culminates with students writing a grant proposal in the style of the NIH NRSA. ##### [NEUROBIO 327R](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22:true,%22SaveRecent%22:true,%22Facets%22:%5B%5D,%22PageNumber%22:1,%22SortOrder%22:%5B%22SCORE%22%5D,%22TopN%22:%22%22,%22PageSize%22:%22%22,%22SearchText%22:%22neurobio%20327r%22%7D). Rotations in Neuroscience This course is designed to introduce new students to labs across the program. The first semester comprises a poster session and series of faculty lightning talks at Harvard Medical School and Harvard University (Cambridge). Students are required to submit at least one rotation registration form per term in the fall and spring of their G1 year in order to receive a passing grade. ### Elective Courses expand\_more In addition to the core courses, PiN students are required to complete 8 credits of elective coursework in order to graduate, including 2 credits of advanced quantitative coursework. PiN strongly encourages students to complete 2 credits of neuroanatomy. At least 4 credits of elective coursework must be completed or in progress before students take their [Preliminary Qualifying Examination](/training/curriculum/pqe) by March 31 of their second year. Students are encouraged to consult with their [SAC advisor](/training/advising-mentorship) and [Dissertation Advisory Committee](/training/advising-mentorship) to select elective courses (either at [Harvard](https://courses.harvard.edu/index.html) or MIT) that fill gaps in their knowledge or allow them to pursue specialized knowledge in subfields pertinent to their research and/or professional development. ##### Recommended Electives [NEUROBIO 209.](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Atrue%2C%22Exclude300%22%3Afalse%2C%22PageSize%22%3A%22%22%2C%22TopN%22%3A%22%22%2C%22PageNumber%22%3A1%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22SaveRecent%22%3Atrue%2C%22CombineClassSections%22%3Atrue%2C%22SearchText%22%3A%22neurobio%20209%22%7D) The Neurobiology of Disease (Spring 2026) [NEUROBIO 212](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20212%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Mathematical Tools for Neuroscientists (Spring 2026) [NEUROBIO 315qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22:true,%22PageNumber%22:1,%22PageSize%22:%22%22,%22SortOrder%22:%5B%22SCORE%22%5D,%22Facets%22:%5B%5D,%22Category%22:%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22,%22SearchPropertiesInResults%22:true,%22FacetsInResults%22:true,%22SaveRecent%22:true,%22TopN%22:%22%22,%22SearchText%22:%22neurobio%20315qc%22,%22DeepLink%22:false%7D). Human Neuroanatomy & Neuropathology (Fall 2026) [NEUROBIO 322qc.](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Atrue%2C%22Exclude300%22%3Afalse%2C%22PageSize%22%3A%22%22%2C%22TopN%22%3A%22%22%2C%22PageNumber%22%3A1%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22SaveRecent%22%3Atrue%2C%22CombineClassSections%22%3Atrue%2C%22SearchText%22%3A%22neurobio%20322qc%22%7D) Advances in synaptic, cellular, and circuit neuroscience (Spring 2026) [NEUROBIO 324qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20324qc%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Evolution of Neuronal Circuitry: Structure, Function and Behavior [NEUROBIO 325qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20325qc%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Advanced Topics in Sensory Neuroscience (Fall 2026) [NEUROBIO 326qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20326qc%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Science Reconsidered [NEUROBIO 327qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20327qc%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Neuronal Diversity [NEUROBIO 328qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22%3Afalse%2C%22PageNumber%22%3A1%2C%22PageSize%22%3A%22%22%2C%22SortOrder%22%3A%5B%22SCORE%22%5D%2C%22Facets%22%3A%5B%5D%2C%22Category%22%3A%22HU_SCL_SCHEDULED_BRACKETED_COURSES%22%2C%22SearchPropertiesInResults%22%3Atrue%2C%22FacetsInResults%22%3Atrue%2C%22SaveRecent%22%3Atrue%2C%22TopN%22%3A%22%22%2C%22SearchText%22%3A%22neurobio%20328qc%22%2C%22DeepLink%22%3Afalse%2C%22CombineClassSections%22%3Atrue%7D). Neurobiology of Behavior [NEUROBIO 333qc](https://portal.my.harvard.edu/psp/hrvihprd/EMPLOYEE/EMPL/h/?tab=HU_CLASS_SEARCH&SearchReqJSON=%7B%22ExcludeBracketed%22:false,%22SaveRecent%22:true,%22Facets%22:%5B%5D,%22PageNumber%22:1,%22SortOrder%22:%5B%22SCORE%22%5D,%22TopN%22:%22%22,%22PageSize%22:%22%22,%22SearchText%22:%22careers%20in%20neuroscience%20(SUBJECT:%5C%22NEUROBIO%5C%22)%22%7D). Careers in Neuroscience PiN students should review the [HMS OGE PhD course listings](https://ogephd.hms.harvard.edu/curriculum) each term to browse elective course offerings. Students can also take [nanocourses](https://curriculumfellows.hms.harvard.edu/nanocourses) offered by the [Curriculum Fellows Program](https://curriculumfellows.hms.harvard.edu/) to satisfy up to 4 credits of elective coursework (3 nanocourses=2 credits, only nanocourses listed on the CFP website are credit-bearing). ## Quick Links [ HMS PhD Courses arrow\_circle\_right ](https://ogephd.hms.harvard.edu/curriculum) [ FAS Registrar arrow\_circle\_right ](https://registrar.fas.harvard.edu/enrollment) [ Academic Calendar arrow\_circle\_right ](https://gsas.harvard.edu/policy/academic-calendar) ![infographic showing PiN curriculum for the first two years](/sites/g/files/omnuum5476/files/2026-03/PiN_curriculum_2026.png) ## Milestones [### Choosing a Lab ](/training/curriculum/rotations) [### Qualifying Exam ](/training/curriculum/pqe) [### DAC Meetings ](/training/advising-mentorship/dac-meetings) [### Dissertation & Defense ](/training/curriculum/dissertation-defense)