# Nitin Joshi Assistant Professor ![headshot of a man with dark hair who is wearing a suit](/sites/g/files/omnuum5476/files/styles/hwp_4_5__320x400/public/2026-11/Joshi.Nitin_.jpg?itok=YiXZDITC) location\_on 60 Fenwood Road, Boston, MA 02115 email laptop\_windows [Lab Website](https://www.thejoshilab.com/) The BioTranslation Laboratory (BTL), based at Brigham and Women's Hospital, Harvard Medical School, and the Broad Institute of MIT and Harvard, develops biointelligent materials for precision therapeutics. We envision medicines that do more than carry therapeutic cargo: they navigate the body, control how long a therapy remains active, and respond intelligently to changing disease biology. Our work advances precision across three interconnected dimensions - targeting, exposure, and intervention. Precision targeting means delivering a therapeutic to the correct organ, tissue, cell, or subcellular compartment. We engineer nanoparticles, hydrogels, and locally administered biomaterials that overcome biological barriers and concentrate small molecules, biologics, and genetic medicines at sites of disease. We are particularly interested in accessing complex tissues, including brain and nervous system, while minimizing off-target effects. Precision exposure means controlling not only the dose, but also the duration and pattern of therapeutic activity. We create long-acting injectable and implantable systems that maintain treatment over weeks or months. By replacing repeated administration with sustained and locally controlled delivery, these technologies could improve efficiency, reduce toxicity, and make otherwise impractical therapies clinically viable. Precision intervention recognizes that disease is dynamic, while most treatments remain static. We design biointelligent materials that sense molecular or physical features of diseased tissues and adjust therapeutic activity accordingly. These systems could intensify treatments as disease progresses, remain inactive in healthy tissue, and ultimately adapt to individual patients. Translation shapes every stage of our research, from material design and scalable manufacturing to pharmacology, safety, and clinically practical administration. By bringing together engineering, pharmacology, safety, and clinically practical administration. By bringing together engineering, neuroscience, and medicine, we aim to create a new generation of drug and gene delivery systems and train scientists who want to transform bold ideas into therapies that meaningfully improve patients' lives. - ## Research Interests [Gene Expression](/research-interests/gene-expression) [Neuropathology & Disease](/research-interests/neuropathology-disease) [Neuropharmacology & Neurochemistry](/research-interests/neuropharmacology-neurochemistry) - ## Research Techniques [Behavioral](/research-technique/behavioral) [Biochemical/Protein Chemistry](/research-technique/biochemicalprotein-chemistry) [Imaging (microscopic and/or functional)](/research-technique/imaging-microscopic-andor-functional) [Molecular Biological and Genetic](/research-technique/molecular-biological-and-genetic) [Neuroanatomical](/research-technique/neuroanatomical) [Neuronal Tissue and Cell Culture](/research-technique/neuronal-tissue-and-cell-culture) - ## People [Faculty](/people/faculty)