# Alice Stanton Assistant Professor ![headshot of woman with blonde hair smiling at the camera](/sites/g/files/omnuum5476/files/styles/hwp_4_5__320x400/public/2026-11/Alice_Stanton_resized.jpg?itok=FyX2-Z_T) location\_on Simches Research Building 5242, 185 Cambridge St, Boston, MA 02114 email laptop\_windows [Lab Website](https://www.stantonlab.info/) laptop\_windows [Publications](https://pubmed.ncbi.nlm.nih.gov/?term=stanton+alice+e) The Stanton Laboratory works at the interface of neuroscience, engineering, and biotechnology. We aim to advance a personalized medicine pipeline for neurological disease by developing and leveraging novel discovery platforms and drug delivery paradigms, integrated with machine learning approaches. We have a strong interest in subtyping neurological disease to address underlying mechanisms on a patient-specific basis. We further aim to understand how disparate variants converges in shared pathologies and identify contributors to sporadic disease. To identify therapeutic targets and putative drug candidates, we combine human cell-based preclinical models, in vivo discovery platforms, and machine learning approaches. At the same time, one of the most formidable challenges in developing effective neurotherapeutics is successfully delivering treatments to the brain - an organ well-protected by tightly regulated brain barriers, including the blood-brain barrier (BBB). To address this, we probe routes to the brain to advance understanding, while we engineer carriers for enhanced delivery, develop targeted delivery strategies, and employ nanotechnology approaches. Concomitantly, a critical bottleneck to translating genetic variant discovery into therapeutic strategies is understanding the functional consequences of the variant. As many risk variants reside in non-coding and regulatory regions not well-conserved in other animals, human cell-based systems provide unique advantages for decoding variant effects. We develop variant-specific models to probe phenotypes on both a cell type-specific basis and the tissue scale, resultant from multicellular crosstalk, including via the multicellular integrated brain model, miBrain, and perfusable miBrain-on-Chip platforms we developed. These synergistic questions and approaches converge in our laboratory to promote innovation and discovery in neurological disease understanding and treatment and form an interdisciplinary training environment. - ## Research Interests [Neuropathology & Disease](/research-interests/neuropathology-disease) [Neuropharmacology & Neurochemistry](/research-interests/neuropharmacology-neurochemistry) - ## Research Techniques [Behavioral](/research-technique/behavioral) [Biochemical/Protein Chemistry](/research-technique/biochemicalprotein-chemistry) [Computational](/research-technique/computational) [Electrophysiological](/research-technique/electrophysiological) [Imaging (microscopic and/or functional)](/research-technique/imaging-microscopic-andor-functional) [Molecular Biological and Genetic](/research-technique/molecular-biological-and-genetic) [Neuroanatomical](/research-technique/neuroanatomical) [Neuronal Tissue and Cell Culture](/research-technique/neuronal-tissue-and-cell-culture) [Non-Mammalian Systems](/research-technique/non-mammalian-systems) - ## People [Faculty](/people/faculty)